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| Chemicals in sugar can destroy metabolism and cause diabetes |
The flies experiment found that a large amount of metabolite MG (methylglyoxal) caused a typical metabolic disorder in diabetes.
This leads to increased insulin resistance, obesity and blood sugar levels.
High levels of MG (found in sugar) cause typical diabetes problems and flies metabolism
Dr. Aurelio Taylorman of the German Cancer Research Center in Heidelberg said: "Increased MG levels seem to be sufficient to trigger insulin resistance and typical metabolic disorders of diabetes."
This is clear evidence that MG is not the result, but the cause of type 2 diabetes. under these circumstances
The findings, published in the journal Cell Metabolism, also raise the question of what may lead to elevated levels of MG.
For example, non-diabetic obese people also show elevated levels of MG.
Co-author Dr. Peter Navarros said: "Why is this, we don't know." This is an important aspect of our future research. under these circumstances
diabetes. Influenced more than 4 million Britons. This discovery may lead to the development of drugs for MG.
This compound has a high concentration in Manuka honey, which is 100 times that of regular honey and is considered to have antiseptic effect.
Increased insulin resistance and elevated blood glucose levels are thought to be responsible for type 2 diabetes, which is caused by obesity.
It usually occurs in the elderly and causes serious health complications. It can cause heart disease and stroke, massive blood flow problems in the legs, and severe damage to the eyes, nerves and kidneys.
The late effects of these dangers are thought to be caused by hyperglycemia, which is elevated when body cells no longer respond to insulin.
This is a hormone that lowers blood sugar.
But Dr. Taylorman and his colleagues say the situation may be completely different.
Blood glucose levels are associated with symptoms of diabetes. When drugs are used to lower very high blood glucose levels, the incidence of infarction and stroke and blood flow problems is simultaneously reduced.
Dr. Nawroth of Heidelberg University Hospital said: "But this situation is only established to a certain extent.
Numerous clinical trials in recent years have shown that many patients develop typical diabetic neurological and renal damage even when blood glucose can be lowered by drugs below the diabetes threshold.
This suggests that type 2 diabetes may actually have molecular causes that are independent of insulin and glucose. under these circumstances
The researchers knew that high levels of MG were observed in patients with type 2 diabetes and thought it was the result of elevated blood glucose.
Because MG can cause damage to proteins, knowledge in textbooks suggests that it must be one of the main causes of typical diabetes damage.
But according to their recent findings, metabolic experts now suspect this series of events.
When rats are given MG food, they develop many typical symptoms of diabetes, including insulin resistance.
The researchers plan to study the effects of long-term high MG concentrations on the body.
They chose fruit flies as a model for this purpose.
Dr. Taylorman explained: "The relationship between flies and humans is not very close.
However, since energy metabolism develops very early in the evolution process, the results still make sense and can usually be transformed into mammals and humans. under these circumstances
Using genetic engineering, the researchers turned off enzymes that break down MG in flies.
Glucose metabolites MG are subsequently accumulated in their bodies. Flies quickly develop insulin resistance.
Later, they became obese and their glucose levels became disordered at higher ages.
Dr. Taylorman said: "The production and decomposition of MG is affected by many metabolic processes, and we do not know that these processes must be better understood.
We also urgently plan to study in mammals which clinical symptoms of long-term elevated MG levels cause mammals.
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